The potent signaling molecule SCUBE3 just might reshape the entire future of hair loss for men and women alike.
Although there is great hope for the future of SCUBE3, it won't be happening immediately.
Scientists have found that SCUBE3 was being expressed in the mutant mice but not in the controls.
That didn’t mean anything on its own, however, because SCUBE3 could’ve just been a bystander molecule.
1. They deleted it from mice.2. They injected it into normal mice.
3. They injected it into mice with human hair follicles grafted onto their skins.
The normal mice, as well as the ones with human hair follicles, showed that SCUBE3 drives hair growth and, in a crucial manner, as shown by experiments, human hair growth.
"At first, nothing would happen. But then, as days went by, all of a sudden, boom, the mutant mouse grew hair like there was no tomorrow, and that was the 'Ah ha' moment."
"Then we knew we had a really hairy mouse," said Maksim Plikus, Ph.D. UC Irvine professor of developmental & cell biology (chief scientific officer of hair biotech company Amplifica) and one of the study's authors.
A key aspect of hair loss with age is the aging of the hair follicle. Ordinarily, hair follicle renewal is maintained by the stem cells associated with each follicle.
Aging of the hair follicle appears to be primed by a sustained cellular response to the DNA damage that accumulates in renewing stem cells during aging.
Proteolysis of collagen leads to the elimination of the damaged cells and, consequently, to terminal hair follicle miniaturization.
In June 2022, the University of California, Irvine, announced that researchers have discovered that hedgehog signaling in murine fibroblasts induces new hair growth.
It also triggers hair multiplication. Hedgehog activation increases fibroblast heterogeneity. It drives new cell states.
A new signaling molecule called SCUBE3 potently stimulates hair growth. It may offer therapeutic treatment for androgenetic alopecia (AGA, pattern baldness).
The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians.
Fruit fly larvae lacking the Hh gene are said to resemble hedgehogs.
Larvae without Hh are short and spiny, resembling the hedgehog animal.
Overactivation of Hedgehog signaling in the niche dramatically accelerates hair growth. It induces follicle multiplication in mice.
These recent scientific discoveries bring great new hope for reversing and regrowing hair in those with androgenetic alopecia (AGA).
The bad news? It may not happen immediately.
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