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Term: Apigen

Apigen is a plant compound derived from Chinese medicine for antibacterial, anti-inflammatory, and antiviral uses.

Apigen is found in celery and celery juice.  The juice also provides luteolin, a flavonoid with anti-cancer properties.

In recent years interest in apigenin as a beneficial and health-promoting agent has grown.

Apigenin promotes different anti-inflammatory pathways, including p38/MAPK and PI3K/Akt, as well as prevent the IKB degradation and nuclear translocation of the NF-κB and reduce COX-2 activity.

After absorption into the digestive tract, apigenin can reach the brain through the circulatory system, crossing the blood-brain barrier before exerting its affinity with the GABAA-receptor and acting on the CNS, despite its action at the level of improving the clinical use of benzodiazepines is not clear.

Reference:  The Therapeutic Potential of Apigenin




2019 Mar; 20(6): 1305.



Published online 2019 Mar 15. doi: 10.3390/ijms20061305





PMCID: PMC6472148



PMID: 30875872


 
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